Inhibition of leukotriene omega-oxidation by isonicotinic acid hydrazide (isoniazid)

Isonicotinic Acid Hydrazide

A simple blood medium for determining the susceptibility of Mycobacterium tuberculosis to isoniazid (isonicotinic acid hydrazide).

In previous studies (Tanrhis and Frisch, 1951a,b) it was found that a human blood medium was satisfactory for determining the susceptibility of Mycobacterium tuberculosis to streptomycin. This investigation was undertaken to determine whether the same medium would be suitable also for performing isoniazid susceptibility tests, and to compare it with the American Trudeau Society (Report of the C...

Detection and identification of some metabolites of isonicotinic acid hydrazide (isoniazid) in human urine.

Kelly, Poet & Chesner (1952) have investigated the metabolic fate of isoniazid (pyridine-4-carboxyhydrazide)' in dogs. After the oral administration of isoniazid (5 and 20 mg./kg. body weight), 20-50% of the drug was excreted unchanged in the first and 1-5% in the second 24 hr. isoNicotinic acid was isolated and identified as a major metabolite, 20-40% ofthe dose being excreted in this form. Th...

Pyridoxine-responsive anemia conditioned by isonicotinic acid hydrazide.

S INCE THE FIRST report in 1956 of a patient with pyridoxine-responsive anemia, a number of other patients have been reported.”2 The red blood cells usually are hypochromic and microcytic but occasionally they may be macrocytic and accompanied by megaboblastic bone marrow maturation. It is unlikely that many of these patients have a simple dietary deficiency of pyridoxine, since barge doses of ...

Carcinogenesis in Swiss mice by isonicotinic acid hydrazide.

There have been several demonstrations of the limited tumorigenicity of INH in mice. The 1st such experiment was re ported by Juhász et al. (3, 4), who reported the induction of pulmonary adenomas, lymphomas, and leukemia.s in randomly bred mice injected i.p. with INH. In a subsequent study these same investigators found only an induction in lymphomas and leukemias but reported the occurrence ...